ABSTRACT This research investigates the effect of fertility rate and mortality rate on population growth in Uganda from 1960-2015. Using both multiple and simple regression analysis, my objectives were; to find out the trend of mortality rate in Uganda, to find out the trend of fertility rate in Uganda, to find out the trend of population growth in Uganda, to investigate the effect of fertility rate on population growth in Uganda, to investigate the effect of mortality rate on population growth in Uganda and to investigate the effect of fertility rate on mortality rate in Uganda. The study followed a quantitative, correlational and descriptive design and it involved multiple and linear regression of the variables. From the analysis carried out, I found out that both fertility rate and mortality rate are both decreasing and evidenced from the trend chats but population growth has experienced a steady increase over the study period. Mortality rate and fertility rate had a negative effect on population growth. Mortality rate had a positive effect on fertility rate. From the purpose of the study that was investigating the effect of mortality rate and fertility rate on population growth in Uganda and I found out that both fertility rate and mortality rate had a significant effect on population growth in Uganda. However, the two independent variables were highly correlated and out of the regressions of each independent variables with population growth and by comparing the R2 values and the standard errors, I found out that mortality rate had a more significant effect on population growth than fertility rate since it had a high R2 value and least standard error. In conclusion, mortality rate is more significant in determining population growth in Uganda from 1960-2015.